diff --git a/pkgs/development/python-modules/opentelemetry-api/default.nix b/pkgs/development/python-modules/opentelemetry-api/default.nix
index 72957901af41..5b59d43e7816 100644
--- a/pkgs/development/python-modules/opentelemetry-api/default.nix
+++ b/pkgs/development/python-modules/opentelemetry-api/default.nix
@@ -14,7 +14,7 @@
 let
   self = buildPythonPackage rec {
     pname = "opentelemetry-api";
-    version = "1.21.0";
+    version = "1.22.0";
     disabled = pythonOlder "3.7";
 
     # to avoid breakage, every package in opentelemetry-python must inherit this version, src, and meta
@@ -22,7 +22,7 @@ let
       owner = "open-telemetry";
       repo = "opentelemetry-python";
       rev = "refs/tags/v${version}";
-      hash = "sha256-igG0oHRa6M4d7pMp7fgBo13x5XADZeYgFAL8WzDXsyw=";
+      hash = "sha256-6BmBmooVaH1FOpgXpFlYth0r9XaNtmb9UezeP8hWEok=";
     };
 
     sourceRoot = "${src.name}/opentelemetry-api";
diff --git a/pkgs/development/python-modules/opentelemetry-instrumentation-flask/default.nix b/pkgs/development/python-modules/opentelemetry-instrumentation-flask/default.nix
new file mode 100644
index 000000000000..71860dd8fd74
--- /dev/null
+++ b/pkgs/development/python-modules/opentelemetry-instrumentation-flask/default.nix
@@ -0,0 +1,45 @@
+{ buildPythonPackage
+, flask
+, hatchling
+, opentelemetry-api
+, opentelemetry-instrumentation
+, opentelemetry-instrumentation-wsgi
+, opentelemetry-semantic-conventions
+, opentelemetry-test-utils
+, opentelemetry-util-http
+, pytestCheckHook
+, pythonOlder
+}:
+
+buildPythonPackage {
+  inherit (opentelemetry-instrumentation) version src;
+  pname = "opentelemetry-instrumentation-flask";
+  disabled = pythonOlder "3.7";
+
+  sourceRoot = "${opentelemetry-instrumentation.src.name}/instrumentation/opentelemetry-instrumentation-flask";
+
+  format = "pyproject";
+
+  nativeBuildInputs = [ hatchling ];
+
+  propagatedBuildInputs = [
+    flask
+    opentelemetry-api
+    opentelemetry-instrumentation
+    opentelemetry-instrumentation-wsgi
+    opentelemetry-semantic-conventions
+    opentelemetry-util-http
+  ];
+
+  nativeCheckInputs = [
+    opentelemetry-test-utils
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [ "opentelemetry.instrumentation.flask" ];
+
+  meta = opentelemetry-instrumentation.meta // {
+    homepage = "https://github.com/open-telemetry/opentelemetry-python-contrib/blob/main/instrumentation/opentelemetry-instrumentation-flask";
+    description = "Flask Middleware for OpenTelemetry based on the WSGI middleware";
+  };
+}
diff --git a/pkgs/development/python-modules/opentelemetry-instrumentation/default.nix b/pkgs/development/python-modules/opentelemetry-instrumentation/default.nix
index 4ee758ea564d..f5e76507d3ab 100644
--- a/pkgs/development/python-modules/opentelemetry-instrumentation/default.nix
+++ b/pkgs/development/python-modules/opentelemetry-instrumentation/default.nix
@@ -13,7 +13,7 @@
 
 buildPythonPackage rec {
   pname = "opentelemetry-instrumentation";
-  version = "1.16.0";
+  version = "0.43b0";
   disabled = pythonOlder "3.7";
 
   # to avoid breakage, every package in opentelemetry-python-contrib must inherit this version, src, and meta
@@ -21,7 +21,7 @@ buildPythonPackage rec {
     owner = "open-telemetry";
     repo = "opentelemetry-python-contrib";
     rev = "refs/tags/v${version}";
-    hash = "sha256-6tGQjPBej2zv5yJN0S46le3kyD7q3TELYyDmyxlp5Wo=";
+    hash = "sha256-fUyA3cPXAxO506usEWxOUX9xiapc8Ocnbx73LP6ghRE=";
   };
 
   sourceRoot = "${src.name}/opentelemetry-instrumentation";
diff --git a/pkgs/development/python-modules/opentelemetry-util-http/default.nix b/pkgs/development/python-modules/opentelemetry-util-http/default.nix
index 85e28f2a6d49..e14338ffcbce 100644
--- a/pkgs/development/python-modules/opentelemetry-util-http/default.nix
+++ b/pkgs/development/python-modules/opentelemetry-util-http/default.nix
@@ -33,6 +33,12 @@ buildPythonPackage {
     pytestCheckHook
   ];
 
+  # https://github.com/open-telemetry/opentelemetry-python-contrib/issues/1940
+  disabledTests = [
+    "test_nonstandard_method"
+    "test_nonstandard_method_allowed"
+  ];
+
   pythonImportsCheck = [ "opentelemetry.util.http" ];
 
   meta = opentelemetry-instrumentation.meta // {
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 427b753a922c..4177ee78eb41 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8772,6 +8772,8 @@ self: super: with self; {
 
   opentelemetry-instrumentation-django = callPackage ../development/python-modules/opentelemetry-instrumentation-django { };
 
+  opentelemetry-instrumentation-flask = callPackage ../development/python-modules/opentelemetry-instrumentation-flask { };
+
   opentelemetry-instrumentation-grpc = callPackage ../development/python-modules/opentelemetry-instrumentation-grpc { };
 
   opentelemetry-instrumentation-wsgi = callPackage ../development/python-modules/opentelemetry-instrumentation-wsgi { };