diff --git a/pkgs/development/python-modules/webapp2/default.nix b/pkgs/development/python-modules/webapp2/default.nix
deleted file mode 100644
index 841fb5bd74b6..000000000000
--- a/pkgs/development/python-modules/webapp2/default.nix
+++ /dev/null
@@ -1,28 +0,0 @@
-{ lib
-, buildPythonPackage
-, fetchPypi
-, webob
-, six
-}:
-
-buildPythonPackage rec {
-  pname = "webapp2";
-  version = "2.5.2";
-
-  src = fetchPypi {
-    inherit pname version;
-    sha256 = "997db622a266bd64eb7fcc9cfe823efb69277544aa92064030c16acbfb2733a5";
-  };
-
-  # # error in tests when running with python 3+
-  doCheck = false;
-
-  propagatedBuildInputs = [ webob six ];
-
-  meta = with lib; {
-    description = "Taking Google App Engine's webapp to the next level";
-    homepage = "http://webapp-improved.appspot.com";
-    license = licenses.asl20;
-    maintainers = [ maintainers.costrouc ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 5e421b9c3369..4d752916bffc 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -152,6 +152,7 @@ mapAliases ({
   tensorflow-tensorboard_2 = tensorflow-tensorboard; # added 2021-11-25
   tvnamer = throw "tvnamer was moved to pkgs.tvnamer"; # added 2021-07-05
   WazeRouteCalculator = wazeroutecalculator; # added 2021-09-29
+  webapp2 = throw "webapp2 is unmaintained since 2012"; # added 2022-05-29
   websocket_client = websocket-client; # added 2021-06-15
   xenomapper = throw "xenomapper was moved to pkgs.xenomapper"; # added 2021-12-31
   zc-buildout221 = zc-buildout; # added 2021-07-21
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index dd21231dfecd..b4b3e1eff5aa 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -10979,8 +10979,6 @@ in {
 
   webargs = callPackage ../development/python-modules/webargs { };
 
-  webapp2 = callPackage ../development/python-modules/webapp2 { };
-
   webassets = callPackage ../development/python-modules/webassets { };
 
   web = callPackage ../development/python-modules/web { };