diff --git a/pkgs/applications/science/biology/bowtie2/default.nix b/pkgs/applications/science/biology/bowtie2/default.nix
index 356e90555f8d..dbcecb7ac3fb 100644
--- a/pkgs/applications/science/biology/bowtie2/default.nix
+++ b/pkgs/applications/science/biology/bowtie2/default.nix
@@ -12,14 +12,14 @@
 
 stdenv.mkDerivation (finalAttrs: {
   pname = "bowtie2";
-  version = "2.5.2";
+  version = "2.5.3";
 
   src = fetchFromGitHub {
     owner = "BenLangmead";
     repo = "bowtie2";
     rev = "refs/tags/v${finalAttrs.version}";
     fetchSubmodules = true;
-    hash = "sha256-rWeopeYuCk9ZhJX2SFCcxZWcjXjjTiVRiwkzLQcIgd0=";
+    hash = "sha256-vjJRA9KFfJChxxg2wxBkwsnDw7fx5SNH3JhRXQw+7XA=";
   };
 
   # because of this flag, gcc on aarch64 cannot find the Threads