diff --git a/pkgs/applications/science/biology/macse/default.nix b/pkgs/applications/science/biology/macse/default.nix
new file mode 100644
index 000000000000..59938addbe82
--- /dev/null
+++ b/pkgs/applications/science/biology/macse/default.nix
@@ -0,0 +1,32 @@
+{ stdenv, fetchurl, jre, makeWrapper }:
+
+stdenv.mkDerivation rec {
+  pname = "macse";
+  version = "2.03";
+
+  src = fetchurl {
+    url = "https://bioweb.supagro.inra.fr/${pname}/releases/${pname}_v${version}.jar";
+    sha256 = "0jnjyz4f255glg37rawzdv4m6nfs7wfwc5dny7afvx4dz2sv4ssh";
+  };
+
+  nativeBuildInputs = [ makeWrapper ];
+
+  dontBuild = true;
+  unpackPhase = ":";
+
+  installPhase = ''
+    runHook preInstall
+    mkdir -p $out/share/java
+    cp -s $src $out/share/java/macse.jar
+    makeWrapper ${jre}/bin/java $out/bin/macse --add-flags "-jar $out/share/java/macse.jar"
+    runHook postInstall
+  '';
+
+  meta = with stdenv.lib; {
+    description = "Multiple alignment of coding sequences";
+    homepage = "https://bioweb.supagro.inra.fr/macse/";
+    license = licenses.gpl2;
+    maintainers = [ maintainers.bzizou ];
+    platforms = platforms.all;
+  };
+}
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 4a438540b081..474210e244d5 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -22923,6 +22923,8 @@ in
 
   kallisto = callPackage ../applications/science/biology/kallisto { };
 
+  macse = callPackage ../applications/science/biology/macse { };
+
   migrate = callPackage ../applications/science/biology/migrate { };
 
   mirtk = callPackage ../development/libraries/science/biology/mirtk { };