diff --git a/pkgs/applications/science/biology/ants/default.nix b/pkgs/applications/science/biology/ants/default.nix
index ac332f271662..873cb28b5161 100644
--- a/pkgs/applications/science/biology/ants/default.nix
+++ b/pkgs/applications/science/biology/ants/default.nix
@@ -1,26 +1,18 @@
-{ lib, stdenv, fetchFromGitHub, fetchpatch, cmake, makeWrapper, itk4, vtk_7, Cocoa }:
+{ lib, stdenv, fetchFromGitHub, cmake, makeWrapper, itk-unstable, vtk_8, Cocoa }:
 
 stdenv.mkDerivation rec {
   pname    = "ANTs";
-  version = "2.2.0";
+  version = "2.4.1";
 
   src = fetchFromGitHub {
     owner  = "ANTsX";
     repo   = "ANTs";
-    rev    = "37ad4e20be3a5ecd26c2e4e41b49e778a0246c3d";
-    sha256 = "1hrdwv3m9xh3yf7l0rm2ggxc2xzckfb8srs88g485ibfszx7i03q";
+    rev    = "v${version}";
+    sha256 = "sha256-sRZwRRqqU0xiu4K6xlLQV4xzVNnzMlnRsk+TPiv0wD0=";
   };
 
-  patches = [
-    # Fix build with gcc8
-    (fetchpatch {
-      url = "https://github.com/ANTsX/ANTs/commit/89af9b2694715bf8204993e032fa132f80cf37bd.patch";
-      sha256 = "1glkrwa1jmxxbmzihycxr576azjqby31jwpj165qc54c91pn0ams";
-    })
-  ];
-
   nativeBuildInputs = [ cmake makeWrapper ];
-  buildInputs = [ itk4 vtk_7 ] ++ lib.optionals stdenv.isDarwin [ Cocoa ];
+  buildInputs = [ itk-unstable vtk_8 ] ++ lib.optionals stdenv.isDarwin [ Cocoa ];
 
   cmakeFlags = [ "-DANTS_SUPERBUILD=FALSE" "-DUSE_VTK=TRUE" ];
 
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index f969876f818e..bcba8163bfaf 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -33936,7 +33936,6 @@ with pkgs;
   angsd = callPackage ../applications/science/biology/angsd { };
 
   ants = callPackage ../applications/science/biology/ants {
-    stdenv = if stdenv.cc.isGNU && stdenv.system == "x86_64-linux" then gcc10Stdenv else stdenv;
     inherit (darwin.apple_sdk.frameworks) Cocoa;
   };