diff --git a/pkgs/applications/science/biology/bowtie2/default.nix b/pkgs/applications/science/biology/bowtie2/default.nix
index 1702079e017f..954b704be0c6 100644
--- a/pkgs/applications/science/biology/bowtie2/default.nix
+++ b/pkgs/applications/science/biology/bowtie2/default.nix
@@ -2,13 +2,13 @@
 
 stdenv.mkDerivation rec {
   pname = "bowtie2";
-  version = "2.4.5";
+  version = "2.5.1";
 
   src = fetchFromGitHub {
     owner = "BenLangmead";
     repo = pname;
     rev = "v${version}";
-    sha256 = "sha256-xCsTkQXrZS+Njn0YfidhPln+OwVfTXOqbtB0dCfTP2U=";
+    sha256 = "sha256-HaiZmWU6akHXJVWBmCvkG2E61NDrAP7UIxx9DNCEZqE=";
   };
 
   nativeBuildInputs = [ cmake ];