diff --git a/pkgs/development/python-modules/cnvkit/default.nix b/pkgs/development/python-modules/cnvkit/default.nix
new file mode 100644
index 000000000000..905b274a0552
--- /dev/null
+++ b/pkgs/development/python-modules/cnvkit/default.nix
@@ -0,0 +1,48 @@
+{ lib
+, fetchPypi
+, rPackages
+, rWrapper
+, buildPythonPackage
+, biopython
+, numpy
+, scipy
+, pandas
+, matplotlib
+, reportlab
+, pysam
+, future
+, pillow
+, pomegranate
+, pyfaidx
+}:
+
+buildPythonPackage rec {
+  pname = "CNVkit";
+  version = "0.9.6";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "1hj8c98s538i0hg5mrz4bw4v07qmcl51rhxq611rj2nglnc9r25y";
+  };
+
+  propagatedBuildInputs = [
+    biopython
+    numpy
+    scipy
+    pandas
+    matplotlib
+    reportlab
+    pyfaidx
+    pysam
+    future
+    pillow
+    pomegranate
+  ];
+
+  meta = with lib; {
+    homepage = "https://cnvkit.readthedocs.io";
+    description = "A Python library and command-line software toolkit to infer and visualize copy number from high-throughput DNA sequencing data";
+    license = licenses.asl20;
+    maintainers = [ maintainers.jbedo ];
+  };
+}
diff --git a/pkgs/development/python-modules/pomegranate/default.nix b/pkgs/development/python-modules/pomegranate/default.nix
index e611e2ea5b10..7054485f3021 100644
--- a/pkgs/development/python-modules/pomegranate/default.nix
+++ b/pkgs/development/python-modules/pomegranate/default.nix
@@ -1,17 +1,17 @@
-{ stdenv, buildPythonPackage, fetchFromGitHub, numpy, scipy, cython, networkx, joblib, nose }:
+{ stdenv, buildPythonPackage, fetchFromGitHub, numpy, scipy, cython, networkx, joblib, nose, pyyaml }:
 
 buildPythonPackage rec {
   pname = "pomegranate";
-  version = "0.8.1";
-  
+  version = "0.11.0";
+
   src = fetchFromGitHub {
     repo = pname;
     owner = "jmschrei";
     rev = "v${version}";
-    sha256 = "085nka5bh88bxbd5vl1azyv9cfpp6grz2ngclc85f9kgccac1djr";
+    sha256 = "0gf7z343ag4g7pfccn1sdap3ihkaxrc9ca75awjhmsa2cyqs66df";
   };
 
-  propagatedBuildInputs = [ numpy scipy cython networkx joblib ];
+  propagatedBuildInputs = [ numpy scipy cython networkx joblib pyyaml ];
 
   checkInputs = [ nose ];
 
@@ -20,9 +20,5 @@ buildPythonPackage rec {
     homepage = https://github.com/jmschrei/pomegranate;
     license = licenses.mit;
     maintainers = with maintainers; [ rybern ];
-
-    # "pomegranate does not yet work with networkx 2.0"
-    # see https://github.com/jmschrei/pomegranate/issues/209
-    broken = true; 
   };
 }
diff --git a/pkgs/development/python-modules/pyfaidx/default.nix b/pkgs/development/python-modules/pyfaidx/default.nix
new file mode 100644
index 000000000000..26c36e70d0cc
--- /dev/null
+++ b/pkgs/development/python-modules/pyfaidx/default.nix
@@ -0,0 +1,24 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, six
+}:
+
+buildPythonPackage rec {
+  pname = "pyfaidx";
+  version = "0.5.5.2";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "1akc8hk8rlw7sv07bv1n2r471acvmxwc57gb69frjpcwggf2phls";
+  };
+
+  propagatedBuildInputs = [ six ];
+
+  meta = with lib; {
+    homepage = "https://github.com/mdshw5/pyfaidx";
+    description = "Python classes for indexing, retrieval, and in-place modification of FASTA files using a samtools compatible index";
+    license = licenses.bsd3;
+    maintainers = [ maintainers.jbedo ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 4e0c9b498acd..454e497ad1dc 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -477,6 +477,8 @@ in {
 
   clustershell = callPackage ../development/python-modules/clustershell { };
 
+  cnvkit = callPackage ../development/python-modules/cnvkit { };
+
   cozy = callPackage ../development/python-modules/cozy { };
 
   codespell = callPackage ../development/python-modules/codespell { };
@@ -881,6 +883,8 @@ in {
 
   pyfakefs = callPackage ../development/python-modules/pyfakefs {};
 
+  pyfaidx = callPackage ../development/python-modules/pyfaidx { };
+
   pyfttt = callPackage ../development/python-modules/pyfttt { };
 
   pyftdi = callPackage ../development/python-modules/pyftdi { };