diff --git a/pkgs/development/tools/simavr/default.nix b/pkgs/development/tools/simavr/default.nix
index 8aa9ccd5388a..11b146e55c5e 100644
--- a/pkgs/development/tools/simavr/default.nix
+++ b/pkgs/development/tools/simavr/default.nix
@@ -1,9 +1,17 @@
-{ lib, stdenv, fetchFromGitHub, libelf, which, pkg-config, freeglut
+{ lib, stdenv, makeSetupHook, fetchFromGitHub, libelf, which, pkg-config, freeglut
 , avrgcc, avrlibc
 , libGLU, libGL
 , GLUT }:
 
-stdenv.mkDerivation rec {
+let
+  setupHookDarwin = makeSetupHook {
+    name = "darwin-avr-gcc-hook";
+    substitutions = {
+      darwinSuffixSalt = stdenv.cc.suffixSalt;
+      avrSuffixSalt = avrgcc.suffixSalt;
+    };
+  } ./setup-hook-darwin.sh;
+in stdenv.mkDerivation rec {
   pname = "simavr";
   version = "1.7";
 
@@ -22,9 +30,8 @@ stdenv.mkDerivation rec {
     "AVR=avr-"
   ];
 
-  NIX_CFLAGS_COMPILE = [ "-Wno-error=stringop-truncation" ];
-
-  nativeBuildInputs = [ which pkg-config avrgcc ];
+  nativeBuildInputs = [ which pkg-config avrgcc ]
+    ++ lib.optional stdenv.isDarwin setupHookDarwin;
   buildInputs = [ libelf freeglut libGLU libGL ]
     ++ lib.optional stdenv.isDarwin GLUT;
 
@@ -35,7 +42,6 @@ stdenv.mkDerivation rec {
   checkTarget = "-C tests run_tests";
 
   meta = with lib; {
-    broken = stdenv.isDarwin;
     description = "A lean and mean Atmel AVR simulator";
     homepage    = "https://github.com/buserror/simavr";
     license     = licenses.gpl3;
diff --git a/pkgs/development/tools/simavr/setup-hook-darwin.sh b/pkgs/development/tools/simavr/setup-hook-darwin.sh
new file mode 100644
index 000000000000..3861e45973ac
--- /dev/null
+++ b/pkgs/development/tools/simavr/setup-hook-darwin.sh
@@ -0,0 +1,34 @@
+
+fixupCFlagsForDarwin() {
+    # Because it’s getting called from a Darwin stdenv, avr-gcc will pick up on
+    # Darwin-specific flags, and it will barf and die on -iframework in
+    # particular. Strip them out, so simavr can compile its test firmware.
+    cflagsFilter='s|-F[^ ]*||g;s|-iframework [^ ]*||g;s|-isystem [^ ]*||g;s|  *| |g'
+
+    # The `CoreFoundation` reference is added by `linkSystemCoreFoundationFramework` in the
+    # Apple SDK’s setup hook. Remove that because avr-gcc will fail due to file not found.
+    ldFlagsFilter='s|/nix/store/[^-]*-apple-framework-CoreFoundation[^ ]*||g'
+
+    # `cc-wrapper.sh`` supports getting flags from a system-specific salt. While it is currently a
+    # tuple, that’s not considered a stable interface, so the derivation will provide them.
+    export NIX_CFLAGS_COMPILE_@darwinSuffixSalt@=${NIX_CFLAGS_COMPILE-}
+    export NIX_LDFLAGS_@darwinSuffixSalt@=${NIX_LDFLAGS-}
+
+    echo removing @darwinSuffixSalt@-specific flags from NIX_CFLAGS_COMPILE for @avrSuffixSalt@
+    export NIX_CFLAGS_COMPILE_@avrSuffixSalt@+="$(sed "$cflagsFilter" <<< "$NIX_CFLAGS_COMPILE")"
+    echo removing @darwinSuffixSalt@-specific flags from NIX_LDFLAGS for @avrSuffixSalt@
+    export NIX_LDFLAGS_@avrSuffixSalt@+="$(sed "$ldFlagsFilter;$cflagsFilter" <<< "$NIX_LDFLAGS")"
+
+    # Make sure the global flags aren’t accidentally influencing the platform-specific flags.
+    export NIX_CFLAGS_COMPILE=""
+    export NIX_LDFLAGS=""
+}
+
+# This is pretty hacky, but this hook _must_ run after `linkSystemCoreFoundationFramework`.
+function runFixupCFlagsForDarwinLast() {
+    preConfigureHooks+=(fixupCFlagsForDarwin)
+}
+
+if [ -z "${dontFixupCFlagsForDarwin-}" ]; then
+    postUnpackHooks+=(runFixupCFlagsForDarwinLast)
+fi