diff --git a/pkgs/development/python-modules/blockfrost-python/default.nix b/pkgs/development/python-modules/blockfrost-python/default.nix
new file mode 100644
index 000000000000..043384e80bf0
--- /dev/null
+++ b/pkgs/development/python-modules/blockfrost-python/default.nix
@@ -0,0 +1,35 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+# Python deps
+, requests
+, setuptools
+}:
+
+buildPythonPackage rec {
+  pname = "blockfrost-python";
+  version = "0.5.3";
+
+  format = "pyproject";
+
+  src = fetchFromGitHub {
+    owner = "blockfrost";
+    repo = "blockfrost-python";
+    rev = "${version}";
+    hash = "sha256-mQ8avjyLARJONYn18neCyuHEuv3ySyCNMe+P4+Dlxck=";
+  };
+
+  propagatedBuildInputs = [
+    requests
+    setuptools
+  ];
+
+  pythonImportsCheck = [ "blockfrost" ];
+
+  meta = with lib; {
+    description = "Python SDK for the Blockfrost.io API";
+    homepage = "https://github.com/blockfrost/blockfrost-python";
+    license = licenses.asl20;
+    maintainers = with maintainers; [ t4ccer ];
+  };
+}
diff --git a/pkgs/development/python-modules/cose/default.nix b/pkgs/development/python-modules/cose/default.nix
new file mode 100644
index 000000000000..c591677b5316
--- /dev/null
+++ b/pkgs/development/python-modules/cose/default.nix
@@ -0,0 +1,43 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+# Python deps
+, attrs
+, cbor2
+, certvalidator
+, cryptography
+, ecdsa
+, setuptools
+}:
+
+buildPythonPackage rec {
+  pname = "cose";
+  version = "1.0.1";
+
+  format = "pyproject";
+
+  src = fetchFromGitHub {
+    owner = "TimothyClaeys";
+    repo = "pycose";
+    rev = "v${version}";
+    hash = "sha256-8d6HebWlSKgx7dmOnT7ZZ5mrMfg6mNWhz1hHPv75XF4=";
+  };
+
+  propagatedBuildInputs = [
+    attrs
+    cbor2
+    certvalidator
+    cryptography
+    ecdsa
+    setuptools
+  ];
+
+  pythonImportsCheck = [ "pycose" ];
+
+  meta = with lib; {
+    description = "A Python implementation of the COSE specification";
+    homepage = "https://github.com/TimothyClaeys/pycose";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ t4ccer ];
+  };
+}
diff --git a/pkgs/development/python-modules/pycardano/default.nix b/pkgs/development/python-modules/pycardano/default.nix
new file mode 100644
index 000000000000..8345a3da2065
--- /dev/null
+++ b/pkgs/development/python-modules/pycardano/default.nix
@@ -0,0 +1,67 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+# Python deps
+, blockfrost-python
+, cbor2
+, cose
+, ecpy
+, frozendict
+, frozenlist
+, mnemonic
+, poetry-core
+, pprintpp
+, pynacl
+, setuptools
+, typeguard
+, websocket-client
+}:
+
+let
+  cose_0_9_dev8 = cose.overridePythonAttrs (old: rec {
+    version = "0.9.dev8";
+    src = (old.src.override {
+      rev = "v${version}";
+      hash = "sha256-/jwq2C2nvHInsgPG4jZCr+XsvlUJdYewAkasrUPVaHM=";
+    });
+    pythonImportsCheck = [ "cose" ];
+  });
+
+in buildPythonPackage rec {
+  pname = "pycardano";
+  version = "0.9.0";
+
+  format = "pyproject";
+
+  src = fetchFromGitHub {
+    owner = "Python-Cardano";
+    repo = "pycardano";
+    rev = "v${version}";
+    hash = "sha256-KRlpGhEzABBh1YWCDcrpW4hyMOhEA1Rla9nh95qdVik=";
+  };
+
+  propagatedBuildInputs = [
+    blockfrost-python
+    cbor2
+    cose_0_9_dev8
+    ecpy
+    frozendict
+    frozenlist
+    mnemonic
+    poetry-core
+    pprintpp
+    pynacl
+    setuptools
+    typeguard
+    websocket-client
+  ];
+
+  pythonImportsCheck = [ "pycardano" ];
+
+  meta = with lib; {
+    description = "A lightweight Cardano library in Python";
+    homepage = "https://github.com/Python-Cardano/pycardano";
+    license = licenses.mit;
+    maintainers = with maintainers; [ t4ccer ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index ed1951b06d49..c39838841801 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -1468,6 +1468,8 @@ self: super: with self; {
 
   block-io = callPackage ../development/python-modules/block-io { };
 
+  blockfrost-python = callPackage ../development/python-modules/blockfrost-python { };
+
   blocksat-cli = callPackage ../development/python-modules/blocksat-cli { };
 
   blosc2 = callPackage ../development/python-modules/blosc2 { };
@@ -2239,6 +2241,8 @@ self: super: with self; {
 
   corsair-scan = callPackage ../development/python-modules/corsair-scan { };
 
+  cose = callPackage ../development/python-modules/cose { };
+
   cot = callPackage ../development/python-modules/cot { };
 
   covCore = callPackage ../development/python-modules/cov-core { };
@@ -8888,6 +8892,8 @@ self: super: with self; {
 
   py-cpuinfo = callPackage ../development/python-modules/py-cpuinfo { };
 
+  pycardano = callPackage ../development/python-modules/pycardano { };
+
   pycrc = callPackage ../development/python-modules/pycrc { };
 
   pycritty = callPackage ../development/python-modules/pycritty { };