diff --git a/pkgs/development/python-modules/autobahn/default.nix b/pkgs/development/python-modules/autobahn/default.nix
index 98f2f16b1f74..fe6ee9f8f9ba 100644
--- a/pkgs/development/python-modules/autobahn/default.nix
+++ b/pkgs/development/python-modules/autobahn/default.nix
@@ -4,25 +4,14 @@
   fetchFromGitHub,
   attrs,
   argon2-cffi,
-  base58,
   cbor2,
   cffi,
-  click,
   cryptography,
-  ecdsa,
-  eth-abi,
-  eth-account,
   flatbuffers,
-  jinja2,
-  hkdf,
   hyperlink,
-  mnemonic,
   mock,
   msgpack,
   passlib,
-  py-ecc,
-  # , py-eth-sig-utils
-  py-multihash,
   py-ubjson,
   pynacl,
   pygobject3,
@@ -32,19 +21,11 @@
   python-snappy,
   pytestCheckHook,
   pythonOlder,
-  # , pytrie
-  rlp,
   service-identity,
   setuptools,
-  spake2,
   twisted,
   txaio,
   ujson,
-  # , web3
-  # , wsaccel
-  # , xbr
-  yapf,
-  # , zlmdb
   zope-interface,
 }@args:
 
@@ -71,13 +52,11 @@ buildPythonPackage rec {
     txaio
   ];
 
-  nativeCheckInputs =
-    [
-      mock
-      pytest-asyncio
-      pytestCheckHook
-    ]
-    ++ optional-dependencies.scram ++ optional-dependencies.serialization ++ optional-dependencies.xbr;
+  nativeCheckInputs = [
+    mock
+    pytest-asyncio
+    pytestCheckHook
+  ] ++ optional-dependencies.scram ++ optional-dependencies.serialization;
 
   preCheck = ''
     # Run asyncio tests (requires twisted)
@@ -92,7 +71,7 @@ buildPythonPackage rec {
   pythonImportsCheck = [ "autobahn" ];
 
   optional-dependencies = rec {
-    all = accelerate ++ compress ++ encryption ++ nvx ++ serialization ++ scram ++ twisted ++ ui ++ xbr;
+    all = accelerate ++ compress ++ encryption ++ nvx ++ serialization ++ scram ++ twisted ++ ui;
     accelerate = [
       # wsaccel
     ];
@@ -122,22 +101,6 @@ buildPythonPackage rec {
       zope-interface
     ];
     ui = [ pygobject3 ];
-    xbr = [
-      base58
-      cbor2
-      click
-      ecdsa
-      eth-abi
-      jinja2
-      hkdf
-      mnemonic
-      py-ecc # py-eth-sig-utils
-      py-multihash
-      rlp
-      spake2
-      twisted # web3 xbr
-      yapf # zlmdb
-    ];
   };
 
   meta = with lib; {
diff --git a/pkgs/development/python-modules/hkdf/default.nix b/pkgs/development/python-modules/hkdf/default.nix
deleted file mode 100644
index f04e486fd73c..000000000000
--- a/pkgs/development/python-modules/hkdf/default.nix
+++ /dev/null
@@ -1,40 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchFromGitHub,
-  nose,
-  setuptools,
-}:
-
-buildPythonPackage {
-  pname = "hkdf";
-  version = "0.0.3";
-  pyproject = true;
-
-  src = fetchFromGitHub {
-    owner = "casebeer";
-    repo = "python-hkdf";
-    rev = "cc3c9dbf0a271b27a7ac5cd04cc1485bbc3b4307";
-    hash = "sha256-i3vJzUI7dpZbgZkz7Agd5RAeWisNWftdk/mkJBZkkLg=";
-  };
-
-  build-system = [ setuptools ];
-
-  pythonImportsCheck = [ "hkdf" ];
-
-  nativeCheckInputs = [ nose ];
-
-  checkPhase = ''
-    runHook preCheck
-
-    nosetests
-
-    runHook postCheck
-  '';
-
-  meta = with lib; {
-    description = "HMAC-based Extract-and-Expand Key Derivation Function (HKDF)";
-    homepage = "https://github.com/casebeer/python-hkdf";
-    license = licenses.bsd2;
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 1898c65622b1..d590c94b5cdf 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -258,6 +258,7 @@ mapAliases ({
   hcs_utils = hcs-utils; # added 2024-01-06
   hdlparse = throw "hdlparse has been removed, it was using setuptools 2to3 translation feature, which has been removed in setuptools 58"; # added 2022-01-18
   hglib = python-hglib; # added 2023-10-13
+  hkdf = throw "hkdf has been removed, as it is no longer maintained upstream."; # added 2024-10-04
   homeassistant-bring-api = bring-api; # added 2024-04-11
   homeassistant-pyozw = throw "homeassistant-pyozw has been removed, as it was packaged for home-assistant which has removed it as a dependency."; # added 2024-01-05
   htmllaundry = throw "htmllaundry has been removed because it is abandoned"; # added 2024-06-04
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 247dae388924..8ef48f81ed57 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -5714,8 +5714,6 @@ self: super: with self; {
 
   hkavr = callPackage ../development/python-modules/hkavr { };
 
-  hkdf = callPackage ../development/python-modules/hkdf { };
-
   hledger-utils = callPackage ../development/python-modules/hledger-utils { };
 
   hlk-sw16 = callPackage ../development/python-modules/hlk-sw16 { };