diff --git a/pkgs/development/python-modules/cramjam/default.nix b/pkgs/development/python-modules/cramjam/default.nix
index da4fec24f36b..e61e75da117f 100644
--- a/pkgs/development/python-modules/cramjam/default.nix
+++ b/pkgs/development/python-modules/cramjam/default.nix
@@ -46,7 +46,13 @@ buildPythonPackage rec {
 
   pytestFlagsArray = [ "cramjam-python/tests" ];
 
-  disabledTestPaths = [ "cramjam-python/benchmarks/test_bench.py" ];
+  disabledTestPaths = [
+    "cramjam-python/benchmarks/test_bench.py"
+    # test_variants.py appears to be flaky
+    #
+    # https://github.com/NixOS/nixpkgs/pull/311584#issuecomment-2117656380
+    "cramjam-python/tests/test_variants.py"
+  ];
 
   pythonImportsCheck = [ "cramjam" ];