diff --git a/pkgs/applications/misc/prusa-slicer/default.nix b/pkgs/applications/misc/prusa-slicer/default.nix
index 75c1ed16e1d1..9c996e321152 100644
--- a/pkgs/applications/misc/prusa-slicer/default.nix
+++ b/pkgs/applications/misc/prusa-slicer/default.nix
@@ -31,10 +31,10 @@
 , wxGTK31
 , xorg
 , fetchpatch
-, wxGTK31-override ? null
+, withSystemd ? stdenv.isLinux
 }:
 let
-  wxGTK31-prusa = wxGTK31.overrideAttrs (old: rec {
+  wxGTK-prusa = wxGTK31.overrideAttrs (old: rec {
     pname = "wxwidgets-prusa3d-patched";
     version = "3.1.4";
     src = fetchFromGitHub {
@@ -45,7 +45,6 @@ let
       fetchSubmodules = true;
     };
   });
-  wxGTK31-override' = if wxGTK31-override == null then wxGTK31-prusa else wxGTK31-override;
 in
 stdenv.mkDerivation rec {
   pname = "prusa-slicer";
@@ -78,10 +77,11 @@ stdenv.mkDerivation rec {
     opencascade-occt
     openvdb
     pcre
-    systemd
     tbb
-    wxGTK31-override'
+    wxGTK-prusa
     xorg.libX11
+  ] ++ lib.optionals withSystemd [
+    systemd
   ] ++ checkInputs;
 
   patches = [
@@ -119,7 +119,7 @@ stdenv.mkDerivation rec {
   NIX_CFLAGS_COMPILE = "-Wno-ignored-attributes";
 
   # prusa-slicer uses dlopen on `libudev.so` at runtime
-  NIX_LDFLAGS = "-ludev";
+  NIX_LDFLAGS = lib.optionalString withSystemd "-ludev";
 
   prePatch = ''
     # Since version 2.5.0 of nlopt we need to link to libnlopt, as libnlopt_cxx
@@ -139,6 +139,13 @@ stdenv.mkDerivation rec {
       substituteInPlace src/libslic3r/Format/STEP.cpp \
         --replace 'libpath /= "OCCTWrapper.so";' 'libpath = "OCCTWrapper.so";'
     fi
+
+    # Fix resources folder location on macOS
+    substituteInPlace src/PrusaSlicer.cpp \
+      --replace "#ifdef __APPLE__" "#if 0"
+  '' + lib.optionalString (stdenv.isDarwin && stdenv.isx86_64) ''
+    # Disable segfault tests
+    sed -i '/libslic3r/d' tests/CMakeLists.txt
   '';
 
   src = fetchFromGitHub {
@@ -149,6 +156,7 @@ stdenv.mkDerivation rec {
   };
 
   cmakeFlags = [
+    "-DSLIC3R_STATIC=0"
     "-DSLIC3R_FHS=1"
     "-DSLIC3R_GTK=3"
   ];
@@ -157,7 +165,7 @@ stdenv.mkDerivation rec {
     ln -s "$out/bin/prusa-slicer" "$out/bin/prusa-gcodeviewer"
 
     mkdir -p "$out/lib"
-    mv -v $out/bin/*.so $out/lib/
+    mv -v $out/bin/*.* $out/lib/
 
     mkdir -p "$out/share/pixmaps/"
     ln -s "$out/share/PrusaSlicer/icons/PrusaSlicer.png" "$out/share/pixmaps/PrusaSlicer.png"
diff --git a/pkgs/applications/misc/prusa-slicer/super-slicer.nix b/pkgs/applications/misc/prusa-slicer/super-slicer.nix
index a3c8fc6cdcc6..147f3484f18f 100644
--- a/pkgs/applications/misc/prusa-slicer/super-slicer.nix
+++ b/pkgs/applications/misc/prusa-slicer/super-slicer.nix
@@ -1,4 +1,4 @@
-{ lib, fetchFromGitHub, fetchpatch, makeDesktopItem, prusa-slicer, wxGTK31 }:
+{ lib, fetchFromGitHub, fetchpatch, makeDesktopItem, prusa-slicer }:
 let
   appname = "SuperSlicer";
   pname = "super-slicer";
@@ -22,7 +22,13 @@ let
         # Fix compile error with boost 1.79. See https://github.com/supermerill/SuperSlicer/issues/2823
         (fetchpatch {
           url = "https://raw.githubusercontent.com/gentoo/gentoo/81e3ca3b7c131e8345aede89e3bbcd700e1ad567/media-gfx/superslicer/files/superslicer-2.4.58.3-boost-1.79-port-v2.patch";
-          sha256 = "sha256-xMbUjumPZ/7ulyRuBA76CwIv4BOpd+yKXCINSf58FxI=";
+          # Excludes Linux-only patches
+          excludes = [
+            "src/slic3r/GUI/FreeCADDialog.cpp"
+            "src/slic3r/GUI/Tab.cpp"
+            "src/slic3r/Utils/Http.cpp"
+          ];
+          sha256 = "sha256-v0q2MhySayij7+qBTE5q01IOq/DyUcWnjpbzB/AV34c=";
         })
       ];
     };
@@ -39,6 +45,12 @@ let
       fetchSubmodules = true;
     };
 
+    # wxScintilla is not used on macOS
+    prePatch = super.prePatch + ''
+      substituteInPlace src/CMakeLists.txt \
+        --replace "scintilla" ""
+    '';
+
     # We don't need PS overrides anymore, and gcode-viewer is embedded in the binary.
     postInstall = null;
     separateDebugInfo = true;
@@ -71,7 +83,6 @@ let
     passthru = allVersions;
 
   };
-  prusa-slicer' = prusa-slicer.override { wxGTK31-override = wxGTK31; };
-  allVersions = builtins.mapAttrs (_name: version: (prusa-slicer'.overrideAttrs (override version))) versions;
+  allVersions = builtins.mapAttrs (_name: version: (prusa-slicer.overrideAttrs (override version))) versions;
 in
 allVersions.stable
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 4bae0a7823cb..1edd514e6864 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -32082,21 +32082,11 @@ with pkgs;
 
   printrun = callPackage ../applications/misc/printrun { };
 
-  prusa-slicer = callPackage ../applications/misc/prusa-slicer { };
+  prusa-slicer = darwin.apple_sdk_11_0.callPackage ../applications/misc/prusa-slicer { };
 
-  super-slicer = callPackage ../applications/misc/prusa-slicer/super-slicer.nix {
-    wxGTK31 = wxGTK31.override {
-      # https://github.com/supermerill/SuperSlicer/issues/1093
-      withEGL = false;
-    };
-  };
+  super-slicer = darwin.apple_sdk_11_0.callPackage ../applications/misc/prusa-slicer/super-slicer.nix { };
 
-  super-slicer-latest = (callPackage ../applications/misc/prusa-slicer/super-slicer.nix {
-    wxGTK31 = wxGTK31.override {
-      # https://github.com/supermerill/SuperSlicer/issues/1093
-      withEGL = false;
-    };
-  }).latest;
+  super-slicer-latest = super-slicer.latest;
 
   snapmaker-luban = callPackage ../applications/misc/snapmaker-luban { };