diff --git a/pkgs/development/tools/profiling/sysprof/capture.nix b/pkgs/development/tools/profiling/sysprof/capture.nix
index e6690fc0c68b..913351ce540a 100644
--- a/pkgs/development/tools/profiling/sysprof/capture.nix
+++ b/pkgs/development/tools/profiling/sysprof/capture.nix
@@ -15,13 +15,14 @@ stdenv.mkDerivation rec {
   ];
 
   mesonFlags = [
-    "-Dwith_sysprofd=none"
+    "-Dsysprofd=none"
+    "-Dgtk=false"
     "-Dlibsysprof=false"
     "-Dlibunwind=false"
     "-Dhelp=false"
-    "-Denable_tools=false"
-    "-Denable_tests=false"
-    "-Denable_examples=false"
+    "-Dtools=false"
+    "-Dtests=false"
+    "-Dexamples=false"
   ];
 
   meta = sysprof.meta // {
diff --git a/pkgs/development/tools/profiling/sysprof/default.nix b/pkgs/development/tools/profiling/sysprof/default.nix
index 118b55197da5..7f03c2d6db80 100644
--- a/pkgs/development/tools/profiling/sysprof/default.nix
+++ b/pkgs/development/tools/profiling/sysprof/default.nix
@@ -4,10 +4,10 @@
 , fetchurl
 , gettext
 , glib
-, gtk3
+, gtk4
 , json-glib
 , itstool
-, libdazzle
+, libadwaita
 , libunwind
 , libxml2
 , meson
@@ -17,19 +17,19 @@
 , polkit
 , shared-mime-info
 , systemd
-, wrapGAppsHook
+, wrapGAppsHook4
 , gnome
 }:
 
 stdenv.mkDerivation rec {
   pname = "sysprof";
-  version = "3.44.0";
+  version = "3.45.0";
 
   outputs = [ "out" "lib" "dev" ];
 
   src = fetchurl {
     url = "mirror://gnome/sources/${pname}/${lib.versions.majorMinor version}/${pname}-${version}.tar.xz";
-    sha256 = "q12fW3GXOzCI1Yob/fHcI8OaAvX85OXpxz4DSxeLAFs=";
+    sha256 = "dpAWjFpDJ9++7b1fD+td79Z2zR1hN8Pn14/Inz1lXy8=";
   };
 
   nativeBuildInputs = [
@@ -41,18 +41,17 @@ stdenv.mkDerivation rec {
     ninja
     pkg-config
     shared-mime-info
-    wrapGAppsHook
-    gnome.adwaita-icon-theme
-    glib
+    wrapGAppsHook4
   ];
 
   buildInputs = [
-    gtk3
+    glib
+    gtk4
     json-glib
     pango
     polkit
     systemd
-    libdazzle
+    libadwaita
     libunwind
   ];